13.12.1 Central neuropathic pain attributed to multiple sclerosis (MS)

Description:
Unilateral or bilateral craniocervical pain with variable presentation, with or without sensory changes, attributed to a demyelinating lesion of the central ascending connections of the trigeminal nerve in a person with multiple sclerosis. It commonly remits and relapses.

Diagnostic criteria:
A. Facial and/or head pain fulfilling criterion C
B. Multiple sclerosis (MS) has been diagnosed, with MRI demonstration of a demyelinating lesion in the brain stem or ascending projections of the trigeminal nuclei
C. Pain has developed in temporal relation to to the demyelinating lesion, or led to its discovery
D. Not better accounted for by another ICHD-3 diagnosis.

Comment:
Non-painful sensory abnormalities (usually dysaesthesia but also, hypoaesthesia, anaesthesia, hypoalgesia, paraesthesia, etc) may coexist with pain in 13.12.1 Central neuropathic pain attributed to multiple sclerosis (MS). Pain may be paroxysmal, as in 13.1.2.4 Painful trigeminal neuropathy attributed to multiple sclerosis (MS) plaque, or continuous.