8.2.5 Combination-analgesic-overuse headache

Diagnostic criteria:
A. Headache fulfilling criteria for 8.2 Medication-overuse headache
B. Regular intake of one or more combination-analgesic medications1,2 on ≥10 days/month for >3 months.

Notes:
1. The term combination-analgesic is used specifically for formulations combining drugs of two or more classes, each with analgesic effect or acting as adjuvants.
2. The combination-analgesic(s) will usually be specified in parenthesis.

Comments:
Many combination-analgesics are marketed. They tend to be widely used by people with headache, and are very commonly implicated in medication-overuse headache. For this reason, 8.2.5 Combination-analgesic-overuse headache has a separate coding.

The most commonly overused combination-analgesics are tablets combining simple analgesics with opioids, butalbital and/or caffeine.