8.1.8 Calcitonin gene-related peptide (CGRP)-induced headache

Headache caused immediately, or after a delay, by acute exposure to calcitonin gene-related peptide (CGRP).

Calcitonin gene-related peptide (CGRP), administered by infusion, causes an immediate headache. It can also cause a delayed headache in migraineurs, on average 5-6 hours after exposure, which fulfils the diagnostic criteria for 1.1 Migraine without aura.

The CGRP antagonist, telcagepant, is effective in the acute treatment of migraine.